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AJT Best of 2015

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The American Journal of Transplantation has
been fortunate to receive many important and
well-conceived manuscripts in 2015. The editors had the difficult task of choosing 10 manuscripts that illustrate the best of transplant research published in the last year. As with any “best of” list, we could not acknowledge many excellent and important manuscripts, but the editors wish to thank all authors who contributed their excellent work to the journal.
Kaul et al illustrate the emerging concept of the balance of negative and positive signals in the alloimmune response. This study emphasizes the importance of upregulation of negative signals in preventing cardiac vasculopathy. Early changes attributable to the recently adopted liver redistricting policy were analyzed by Massie et al demonstrating that the policy is having a measurable effect. O’Leary and colleagues challenge the concept that donor-specific anti–HLA antibodies do not have a negative impact on long-term liver allograft survival. In a provocative study where long-term inhibition of terminal complement (c5) in desensitized patients with donor-specific anti–HLA antibody did not prevent chronic glomerular changes on one year biopsy, Cornell et al challenge the concept that damage is solely complement-mediated. In their Clinical Implications of Basic Science Discoveries review, Larregina et al look at the nervous system’s interactions with both the innate and adaptive immune systems, potentially opening a new and important avenue of research and therapeutics. Freedman et al elucidate the role of APOL1 gene variants and outcomes in renal transplant, providing an elegant explanation for certain ethnic differences in donor organ outcomes. Convincing evidence from Pirsch et al demonstrates that low-dose corticosteroids do not significantly increase the risk of new-onset diabetes mellitus after transplant. Yuan et al explore the interaction of lipids and TH17 activity and open inquiry into metabolism and the immune response, while Fumo et al describe their experience with a large paired kidney exchange program. Finally, Newell et al further explore the role of B cells and potential immune tolerance, finding a consistent signature in a variety of settings.
- Bruce Kaplan, AJT Deputy Editor
Please enjoy complimentary access to these articles below.
Acute and Chronic Rejection: Compartmentalization and Kinetics of Counterbalancing Signals in Cardiac Transplants
AMK Kaul et al.
February 2015
Impact of IgG3 Subclass and C1q-Fixing Donor-Specific HLA Alloantibodies on Rejection and Survival in Liver Transplantation
JG O'Leary et al.
April 2015
Clinical Implications of Basic Science Discoveries: Nociceptive Neurons as Targets to Control Immunity—Potential Relevance for Transplantation
AT Larregina et al.
June 2015
New-Onset Diabetes After Transplantation: Results From a Double-Blind Early Corticosteroid Withdrawal Trial
JD Pirsch et al.
July 2015
Historical Matching Strategies in Kidney Paired Donation: The 7-Year Evolution of a Web-Based Virtual Matching System
DE Fumo et al.
September 2015
Early Changes in Liver Distribution Following Implementation of Share 35
AB Massie et al.
March 2015
Positive Crossmatch Kidney Transplant Recipients Treated With Eculizumab: Outcomes Beyond 1 Year
LD Cornell et al.
May 2015
Apolipoprotein L1 Gene Variants in Deceased Organ Donors Are Associated With Renal Allograft Failure
BI Freedman et al.
June 2015
Hyperlipidemia Promotes Anti-Donor Th17 Responses That Accelerate Allograft Rejection
J Yuan et al.
September 2015
Longitudinal Studies of a B Cell–Derived Signature of Tolerance in Renal Transplant Recipients
KA Newell et al.
November 2015

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